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Mesenchymal Stem Cells (MSCs)

MSC Therapy

Mesenchymal Stem Cells (MSCs) are early passage multipotent progenitor cells derived from human cord tissue that are capable of supporting hematopoiesis and differentiating into multiple lineages (osteogenic, adipogenic, chondrogenic, neurogenic, myogenic, and cardiomyogenic.)

Advantages of Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are advantageous over other stem cells types for a variety of reasons. First, they avoid the ethical issues that surround embryonic stem cell research.

Second, repeated studies have found MSCs to be immuno-privileged, which make them an advantageous cell type for allogeneic transplantation. MSCs reduce both the risks of rejection and complications of transplantation.

Third, there have been advances in the use of umbilical cord mesenchymal stem cells to regenerate human tissues, including cartilage, meniscus, tendons, and bone fractures, because MSCs can exert regenerative effects through homing to sites of damage, paracrine signaling, regulating immune responses, and positively affecting the microenvironment.

MSCs can also be clearly identified by their surface markers as seen in the example COA.

How MSCs Look Under a Microscope

Early Stage of MSC Culture

Umbilical Cord MSCs view at 40x magnification.

MSCs are plastic adherent cells which means they attached to the plastic layers of culture flasks. In this stage of culture, you can begin to see the cells attach to the bottom of the flasks.

 

Mid Stage of MSC Culture

Umbilical Cord MSCs view at 40x magnification.

Once MSCs attach they give a spindle shape appearance and develop in size and robustness. As MSCs divide, population doublings occur and the number of MSC increase.

 

Late Stage of MSC Culture

Umbilical Cord MSCs view at 40x magnification.

As the number of MSC increases during the culture, the space becomes occupied leaving less room for cells to grow. This is called confluency. At this stage, we collect the MSCs for banking and treatments.

 

Mesenchymal Stem Cell Key Points

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Well Characterised

MSCs are a well-characterized population of adult stem cells, with over 36,000 scientific articles published about them.

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Non-Controversial

MSCs avoid the ethical issues of embryonic stem cells, as they can be derived from sources that include adult bone marrow and adipose tissue.

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Diverse Differentiation Potential:

MSCs can form a variety of cell types in the laboratory, including those of both intra– and extra-mesenchymal lineage. These cell types include fat (adipocytes), bone (osteoblasts), skin (dermal cells), nerve (neural cells), cartilage (chondrocytes), muscle (skeletal myocytes), tendons (tenocytes), marrow stroma, ligaments, and more.

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Ease of Growth in Culture:

Advanced knowledge exists for how to grow MSCs in culture, including protocols for isolation, expansion, and differentiation.

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Flexible Propagation:

MSCs can be grown and propagated in culture for extended periods, without losing differentiation potential.

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Role as Regulatory Cells:

MSCs synthesize and secrete a variety of macromolecules that are known regulators of hematopoietic and other regenerative cells.

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Favorable Immune Status:

MSCs lack the co-stimulatory molecules of the B7 family that is required to initiate an immune response. This allows the administration of MSC preparations across MHC barriers without concern for immunological rejection or the need for immunosuppression, making Mesenchymal stem cells a universal stem cells source.

Reach Us

SC21 Group - StemCells21 

2nd fl, Urbis building, Aetas Residence, soi Ruamrudee, Bangkok 10330, Thailand.

+6626507709

info@sc21.com

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